Contents for all chapters
1. Developmental Anatomy
2. Developmental Genetics
3. Cell-Cell Communication in Development
4. Fertilization: Beginning a New Organism
5. Early Development in Selected Invertebrates
6. The Genetics of Axis Specification in Drosophila
7. Amphibians and Fish: Early Development and Axis Formation
8. Birds and Mammals: Early Development and Axis Formation
9. The Emergence of the Ectoderm: Central Nervous System and Epidermis
10. Neural Crest Cells and Axonal Specificity
11. Paraxial and Intermediate Mesoderm
12. Lateral Plate Mesoderm and the Endoderm
13. Development of the Tetrapod Limb
14. Sex Determination
15. Postembryonic Development: Metamorphosis, Regeneration, and Aging
16. The Saga of the Germ Line
17. Medical Aspects of Developmental Biology
18. Developmental Plasticity and Symbiosis
19. Developmental Mechanisms of Evolutionary Change
Cheating Death
Do Humans Undergo Metamorphosis?
The Dangers of Environmental Sex Determinations
- J. E. Lovich
C. elegans movies
Hox Genes and Nematode Development
A Selective History of Induction III
Alternative Sources Of Angioblasts
Angiogenesis Factors in Cancer, AIDS, and Diabetes
Childhood as a New Portion of the Human Life Cycle
Decondensation of Sperm Chromatin
Demonstrating Tissue Affinities
Did Birds Evolve from the Dinosaurs?
Establishment of Original Polarity: Oocyte Organelles
Ethical and Public Policy Issues Concerning Stem Cell Research
- Written by Becky Davis, Paul Riccio, and Meika Hashimoto, and edited by Scott Gilbert
Evidence for Restricted Potency Among Neural Crest Cells
Formation of the Neural Floor Plate
GBP (GSK-3 Binding Protein)
Gene Expression and Macroevolutionary Debates
Holoprosencephaly
Hormonal Control of Yolk Production
Hox Genes and the Evolution of the Tetrapod Limb
Implantation
Knowledge of Alcohol as a Teratogen
MPF and Its Regulators
Morphogenetic Processes
Nutritional Polyphenism in Dung Beetles
Osteoclast Commitment, Differentiation, and Function
- Based on a contribution by Dr. Marla Steinbeck, Orthopedic Research Laboratory, Thomas Jefferson Medical School, Philadelphia, PA.
Paracrine Factors in the Construction and Maintenance of the Blood Vessels
Parkinson's Disease and Development
Patterning of the Mesoderm by Activin
RNA Interference
RNAi
Regulating Blastomere Identity
Regulation of Transcription From Immunoglobin Light Chains
Roles of the Mesencephalon in Chick Embryos
Seasonal Polyphenism in Butterfly Wings
Sex And The Central Nervous System: It's not merely gonadal steroids
Teaching Evolution Through Development
- Scott Gilbert
The 5í and 3í Ends
The par Genes and Anterior-posterior Patterning in the Nematode
The Autonomous Specification of the Endoderm
The Ecogenetics of Neural Tube Closure
The Eye-forming Cascade in Insects and Vertebrates
The Fetal Origins of Adult Disease: The effects of malnutrition on diseases later in life
The Generation of Antibody Response
The Hedgehog Family of Paracrine Factors
The Molecular Biology of Organizer Formation
The Role of the Mesentoblast in Gastropod Evolution
The Search for the Yellow Crescent Myogenic Factor
The Separation of Germ and Soma in Volvox
The Timing of Mesoderm Formation in Xenopus
Transcription Factors and the Development of the Heart
Vera, a Protein Implicated in Vg1 mRNA Transport to the Vegetal Cortex
Vertical and Horizontal Signals from the Organizer
Wnt Proteins
How the Chordates Got a Head
1.1 Conklin's Art and Science:
The Organization and Cell-Lineage of the Ascidian Egg
- Edwin G. Conklin
2.1 Does the Genome or the Cytoplasm Direct Development?:
Baltzer on Boveri
- Fritz Baltzer, 1967
2.1 Does the Genome or the Cytoplasm Direct Development?:
Boveri's 1902 Paper
- Theodor Boveri
2.1 Does the Genome or the Cytoplasm Direct Development?:
The Embryological Origins of the Gene Theory
- Scott F. Gilbert
2.2 The Origins of Developmental Genetics:
Cellular Politics
- Scott F. Gilbert
2.2 The Origins of Developmental Genetics:
Enzymatic Adaptation and the Entrance of Molecular Biology into Embryology
- Scott F. Gilbert
2.2 The Origins of Developmental Genetics:
Induction and the Origins of Developmental Genetics
- Scott F. Gilbert
2.2 The Origins of Developmental Genetics:
Quicktime Movie of Dr. François Jacob
2.2 The Origins of Developmental Genetics:
Quicktime Movie of Salome Glueksohn-Waelsch
2.3 Techniques of DNA Analysis:
Determining Methylation Status: Bisulfite Mapping
2.3 Techniques of DNA Analysis:
Studying DNA Regulatory Elements
2.3 Techniques of DNA Analysis:
Techniques of Molecular Biology
2.3 Techniques of DNA Analysis:
Transgenic Cells and Gene Knock-outs
2.4 Techniques of RNA analysis:
Determining the Function of a Message: Antisense RNA
2.4 Techniques of RNA analysis:
In Situ Hybridizations
2.4 Techniques of RNA analysis:
Microarrays and Macroarrays
2.4 Techniques of RNA analysis:
Reverse-Transcriptase Tolymerase Chain Reaction (RT-PCR)
2.5 Bioinformatics:
An Introduction to Bioinformatics
2.5 Bioinformatics:
Developmental Biology, Bioinformatics and Systems Approaches
2.6 Cloning and Nuclear equivalence:
Evidence for Genomic Equivalence
2.6 Cloning and Nuclear equivalence:
Why Clone Animals?
2.7 Silencing Large Blocks of Chromatin:
Chromatin Diminution
2.8 So You Think You Know What a Gene Is?:
What Makes a DNA Sequence a Gene?
3.2 The Uses of Apoptosis:
Apoptosis and the Removal of Unneeded Cells
3.3 Notch Mutations:
Mutations of Notch Proteins and Their Ligands
4.1 Leeuwenhoek and Images of Homunculi:
Anton von Leeuwenhoek and his perception of spermatozoa
- Adapted from an article by E. G. Ruestow, J. History of Biology 16: 185-224.
4.1 Leeuwenhoek and Images of Homunculi:
Homunculus
- Clara Pinto-Correia
4.2 The Origins of Fertilization Research:
The Reemergence of Sex
- John Farley, 1982
4.3 The Egg and Its Environment:
The Egg in the Real World
4.4 The Lillie-Loeb Dispute Over Sperm-Egg Binding:
Gametes and Spores
- John Farley, 1982
4.4 The Lillie-Loeb Dispute Over Sperm-Egg Binding:
On the Nature of the Process of Fertilization
- Jacques Loeb, 1899
4.4 The Lillie-Loeb Dispute Over Sperm-Egg Binding:
The Invention of Artificial Parthenogenesis
- Philip J. Pauly, 1987
4.4 The Lillie-Loeb Dispute Over Sperm-Egg Binding:
The Mechanism of Fertilization
- F. R. Lillie, 1913
4.5 Blocks to Polyspermy:
On Multipolar Mitosis as a Means of Analysis of the Cell Nucleus
- Theodor Boveri, 1902
4.5 Blocks to Polyspermy:
The Fertilization Reaction in Echinarachnius Parma
- E. E. Just, 1919
4.5 Blocks to Polyspermy:
Theodor Boveri: The Life of a Great Biologist 1862-1915
- Fritz Baltzer, 1967
4.6 Building the Egg's Extracellular Matrix:
Building the Egg's Extracellular Matrix
5.1 Sea Urchin Cell Specification:
Transcription Factor Activation in the Sea Urchin Embryo
5.2 Alfred Sturtevant and the Genetics of Snail Coiling:
Sturtevant's Guess
5.3 Modifications of Cell Fate in Spiralian Eggs:
The Role of the Mesentoblast in Gastropod Evolution
5.3 Modifications of Cell Fate in Spiralian Eggs:
Modification of Spiralian Specification
5.5 P-granule Migration:
P-granule Localization in C. elegans and Asymmetry during First Cleavages
6.1 Drosophila Fertilization:
Fertilization in Drosophila
6.2 The Early Development of Other Insects:
Polyembryony: The Parasitic Wasps
6.2 The Early Development of Other Insects:
Short and Intermediate Germ Band Insects
6.3 Evidence for Gradients in Insect Development:
The Maternal Effect Genes
6.4 Christiane Nüsslein-Volhard and the Molecular Approach to Development:
Christiane Nüsslein-Volhard and Drosophila Embryogenesis
6.5 Asymmetrical Spread of Morphogens:
Asymmetric Movement of Wingless Protein in the Epidermis of Drosophila
6.6 Getting a Head in the Fly:
Genes Involved in Drosophila Brain Development
7.1 Amphibian Development Movies:
Amphibian development movies
7.2 Migration of the Mesodermal Mantle:
Migration of the involuting mesoderm
7.3 Spemann, Mangold, and the Organizer:
A Selective History of Induction
7.3 Spemann, Mangold, and the Organizer:
A Selective History of Induction II
7.6 Competence and Bias:
Competence and Bias
7.7 The Specification of the Endoderm:
The Autonomous Specification of the Endoderm
7.8 Regional Specification:
A Selective History of Early Induction Research IV
7.9 Zebrafish Movies and Genetic Screens:
Zebrafish Genetic Screens
7.9 Zebrafish Movies and Genetic Screens:
Zebrafish Movies
8.1 Epiblast Cell Heterogeneity:
Cellular Heterogeneity in the Epiblast
8.2 Mechanisms of Compaction and the Formation of the Inner Cell Mass:
The Cell Surface and the Mechanism of Compaction
8.3 Human Cleavage and Compaction:
Sex Differences in Cell Divisions
8.4 Placental Functions:
The Structure of Placentas
8.5 Nonidentical Monozygotic Twins:
Non-identical Monozygotic Twins
8.6 Conjoined Twins:
A Social History of Conjoined Twins
8.6 Conjoined Twins:
Types of Conjoined Twins
9.1 Homologous Specification of the Neural Tissue:
Homologous Specification of Neural Tissue between Vertebrates and Arthropods
9.2 Specifying the Brain Boundaries:
Marking the Brain Boundaries
9.3 Constructing the Pituitary Gland:
Pituitary Development
9.4 Cerebellar Mutations of the Mouse:
Development of the Cerebellum: Insights from Mutant Mice
9.5 Constructing the Cerebral Cortex:
Three Genes and their Effects
9.6 Neuronal Growth and the Invention of Childhood:
The Birth of Childhood
9.7 Why Babies Don't See Well:
Why Babies Don’t See Well
9.8 Developmental Genetics of Hair Formation:
Developmental genetics of hair formation
9.9 Normal Variation in Human Hair Production:
Formation of Mammalian Hair
9.10 Mutations of Hair Production:
The Red-Headed League: How melanocytes make red pigment
10.1 Communication between Migrating Neural Crest Cells:
Communication between Migrating Cardiac Neural Crest Cells
10.2 Kallmann Syndrome:
The Kallman Syndrome: Sex, Smell, and Specific Adhesion
10.3 The Evolution of Developmental Neurobiology:
Rita Levi-Montalcini
- Adapted from Purves, D. and Lichtman, J. W. 1985. Principles of Neural Development. Sinauer Associates, Sunderland, MA.
10.3 The Evolution of Developmental Neurobiology:
S. Ramón Y Cajal, R. G. Harrison, and the Beginnings of Neuroembryology
- Viktor Hamburger, 1980
10.3 The Evolution of Developmental Neurobiology:
Viktor Hamburger
- Adapted from D. Purves and J. W. Lichtman 1985. Principles of Neural Development. Sinauer Associates, Sunderland, MA.
10.4 The Pathways of Motor Neurons:
Multiple Guidance Cues in the Motor Neurons Innervating Skeletal Muscles
10.5 Genetic Control of Neuroblast Migration in C. elegans :
Hox Genes and Nematode Development
10.6 The Early Evidence for Chemotaxis:
Earlier Evidence for Chemotaxis
11.1 Calling the Competence of the Somite into Question:
Tbx6 and the Specification of Somitic Mesoderm
11.2 Cranial Paraxial Mesoderm:
Cranial Paraxial Mesoderm
11.3 Muscle Formation:
Myotube Formation: How We Learned that Skeletal Muscle is Made by Cell Fusion
11.4 Paracrine Factors, Their Receptors, and Human Bone Growth:
Specific Functions of Fibroblast Growth Factor Receptors
12.1 Coelom Formation:
Coelom Formation
12.2 Induction of the Lung:
Lung Branching Morphogenesis
13.1 Induction of the AER:
Pathway For The Induction of the AER
14.1 Social Critique of Sex Determination Research:
A Gendered Critique of Sex Determination Hypotheses
14.2 Finding the Male-Determining Genes:
Method for Identifying the Region of the Y-chromosome Containing the Testis Determining Factor in Humans
14.3 Dihydrotestosterone in Adult Men:
5α-Dihydrotestosterone in Adults
14.4 Insulin-like Hormone 3:
Insulin-like Hormone-3 and Secondary Male Sex Determination
14.5 Forms of Hermaphroditism:
Hermaphroditism
14.5 Forms of Hermaphroditism:
Human Hermaphrodites
14.5 Forms of Hermaphroditism:
Normal Hermaphroditism in Nematodes and Fish
15.1 The Molecular Biology of Wing Formation:
Intercellular Interactions Establishing the Dorsal-ventral Wing Surfaces
15.2 Homologous Specification:
Homologous Specification
15.3 Insect Metamorphosis:
Drosophila Metamorphosis
15.3 Insect Metamorphosis:
Hormonal Control of Insect Metamorphosis
15.3 Insect Metamorphosis:
Microarray Analysis Of Drosophila Metamorphosis
15.3 Insect Metamorphosis:
Remodeling The Insect Central Nervous System
15.4 Precocenes and Synthetic JH:
Environmental Control Over Larval Form and Function: Precocenes and Plant Juvenile Hormones
15.5 Regeneration in Annelid Worms:
Annelid Regeneration
15.6 The Polar Coordinate and Boundary Models:
The Polar Coordinate Model of The Polar Coordinate Model of Positional Information in the Developing and Regenerating Limb
15.7 Ethel Browne and the Organizer:
Ethel Browne Harvey (1885-1965) and the Organizer
16.1 Germline Sex Determination in C. elegans :
Translational Regulation of Germline Sex Determination in C. elegans
16.2 Mechanisms of Chromosome Diminution:
Chromatin Diminution
16.3 The Insect Germ Plasm:
The Discovery of Insect Germ Plasm
16.4 Human Meiosis:
Human Meiosis
16.5 The Nebenkern:
Fuzzy Onions and the Nebenkern
16.6 Synthesizing Oocyte Ribosomes:
Synthesizing Ribosomes
16.7 Hormones and Mammalian Egg Maturation:
Hormones and Mammalian Egg Maturation
16.8 The Reinitiation of Mammalian Meiosis:
The Reinitiation of Meiosis in Mammals
17.2 Thalidomide as a Teratogen:
Thalidomide as a Teratogen
17.3 Our Stolen Future:
Our Stolen Future and The Contest for Truth
17.4 Therapeutic Cloning:
Therapeutic Cloning
18.1 Inducible Caste Determination in Ant Colonies:
Inducible Defense in the Ant Colony
18.2 Volvox: When Heat Brings Out Sex:
Volvox: When Heat Brings Out Sex
18.4 Pressure as a Developmental Agent:
Pressure as a Developmental Agent
18.5 The Dictyostelium Life Cycle: Variations within Variations:
The Dictyostelium Life Cycle: Variations within Variations
18.6 Developmental Symbioses and Parasitism:
Developmental Symbiosis as Protection
18.6 Developmental Symbioses and Parasitism:
How Do Symbionts Get Together?
19.1 Relating Evolution to Development in the Nineteenth Century:
Edmund Beecher Wilson and Frank R. Lillie and the relationship between evolution and development
19.3 The Search for the Urbilaterian Ancestor:
The Search for the Urbilaterian Ancestor
19.4 How the Chordates Got a Head:
How the Chordates Got a Head
19.5 "Intelligent Design" and Evolutionary Developmental Biology:
Evolution and "Scientific Creationism"
21.1 Human Embryology and Genetics:
Human Embryology and Genetics
23.2 Haeckel's Biogenetic Law:
Ernst Haeckel and the Biogenetic Law
23.2 Haeckel's Biogenetic Law:
Haeckel and the Vertebrate Archetype
23.6 Correlated Progression:
Developmental Correlation
23.7 Correlated Progression in Domestic Animals:
Evolution and Domestication: Selection on Developmental Genes?
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