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Figure 4
Cartilage development at the growth plate of
the long bones. (A) Normal growth plate showing (upper) region of resting
chondrocytes, a zone of proliferating chondrocytes, a zone of hypertrophic
chondrocytes, and lastly (in the lower portion of the photograph) a region
of vascularization and osteogenesis. (B) Growth plate in thanatophoric dysplasia.
The growth plate is disorganized and shows no region of proliferating chondrocytes.
(C) Photograph of an infant with thanatophoric dysplasia. The bones have
not extended. (Photographs courtesy of Dr. Enid Gilbert.) |
