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I QUESTIONS Introducing Developmental Biology
1. Developmental Anatomy
2. Developmental Genetics
- 2.1 Does the Genome or the Cytoplasm Direct Development?
- 2.2 The Origins of Developmental Genetics
- 2.3 Techniques of DNA Analysis
- 2.4 Techniques of RNA analysis
- 2.5 Bioinformatics
- 2.6 Cloning and Nuclear equivalence
- 2.7 Silencing Large Blocks of Chromatin
- 2.8 So You Think You Know What a Gene Is?
3. Cell-Cell Communication in Development
II SPECIFICATION Introducing Cell Commitment and Early Embryonic Development
4. Fertilization: Beginning a New Organism
- 4.1 Leeuwenhoek and Images of Homunculi
- 4.2 The Origins of Fertilization Research
- 4.3 The Egg and Its Environment
- 4.4 The Lillie-Loeb Dispute Over Sperm-Egg Binding
- 4.5 Blocks to Polyspermy
- 4.6 Building the Egg's Extracellular Matrix
5. Early Development in Selected Invertebrates
- 5.1 Sea Urchin Cell Specification
- 5.2 Alfred Sturtevant and the Genetics of Snail Coiling
- 5.3 Modifications of Cell Fate in Spiralian Eggs
- 5.4 The Experimental Analysis of Tunicate Cell Specification
- 5.5 P-granule Migration
6. The Genetics of Axis Specification in Drosophila
- 6.1 Drosophila Fertilization
- 6.2 The Early Development of Other Insects
- 6.3 Evidence for Gradients in Insect Development
- 6.4 Christiane Nüsslein-Volhard and the Molecular Approach to Development
- 6.5 Asymmetrical Spread of Morphogens
- 6.6 Getting a Head in the Fly
7. Amphibians and Fish: Early Development and Axis Formation
- 7.1 Amphibian Development Movies
- 7.2 Migration of the Mesodermal Mantle
- 7.3 Spemann, Mangold, and the Organizer
- 7.4 The Molecular Biology of Organizer Formation
- 7.5 Early Attempts to Locate the Organizer Molecules
- 7.7 Regional Specification
- 7.8 Competence and Bias
- 7.9 GFP Zebrafish Movies and Photographs
8. Birds and Mammals: Early Development and Axis Formation
- 8.1 Epiblast Cell Heterogeneity
- 8.2 Mechanisms of Compaction and the Formation of the Inner Cell Mass
- 8.3 Human Cleavage and Compaction
- 8.4 Placental Functions
- 8.5 Nonidentical Monozygotic Twins
- 8.6 Conjoined Twins
III THE STEM CELL CONCEPT Introducing Organogenesis
9. The Emergence of the Ectoderm: Central Nervous System and Epidermis
- 9.1 Homologous Specification of the Neural Tissue
- 9.2 Specifying the Brain Boundaries
- 9.3 Constructing the Pituitary Gland
- 9.4 Cerebellar Mutations of the Mouse
- 9.5 Constructing the Cerebral Cortex
- 9.6 Neuronal Growth and the Invention of Childhood
- 9.7 Why Babies Don't See Well
- 9.8 Developmental Genetics of Hair Formation
- 9.9 Normal Variation in Human Hair Production
- 9.10 Mutations of Hair Production
10. Neural Crest Cells and Axonal Specificity
- 10.1 Communication between Migrating Neural Crest Cells
- 10.2 Kallmann Syndrome
- 10.3 The Evolution of Developmental Neurobiology
- 10.4 The Pathways of Motor Neurons
- 10.5 Genetic Control of Neuroblast Migration in C. elegans
- 10.6 The Early Evidence for Chemotaxis
11. Paraxial and Intermediate Mesoderm
- 11.1 Calling the Competence of the Somite into Question
- 11.2 Cranial Paraxial Mesoderm
- 11.3 Muscle Formation
- 11.4 Paracrine Factors, Their Receptors, and Human Bone Growth
12. Lateral Plate Mesoderm and the Endoderm
13. Development of the Tetrapod Limb
14. Sex Determination
- 14.1 Social Critique of Sex Determination Research
- 14.2 Finding the Male-Determining Genes
- 14.3 Dihydrotestosterone in Adult Men
- 14.4 Insulin-like Hormone 3
- 14.5 Forms of Hermaphroditism
15. Postembryonic Development: Metamorphosis, Regeneration, and Aging
- 15.1 The Molecular Biology of Wing Formation
- 15.2 Homologous Specification
- 15.3 Insect Metamorphosis
- 15.4 Precocenes and Synthetic JH
- 15.5 Regeneration in Annelid Worms
- 15.6 The Polar Coordinate and Boundary Models
- 15.7 Ethel Browne and the Organizer
16. The Saga of the Germ Line
- 16.1 Germline Sex Determination in C. elegans
- 16.2 Mechanisms of Chromosome Diminution
- 16.3 The Insect Germ Plasm
- 16.4 Human Meiosis
- 16.5 The Nebenkern
- 16.6 Synthesizing Oocyte Ribosomes
- 16.7 Hormones and Mammalian Egg Maturation
- 16.8 The Reinitiation of Mammalian Meiosis
IV SYSTEMS BIOLOGY Expanding Developmental Biology to Medicine,Ecology, and Evolution
17. Medical Aspects of Developmental Biology
- 17.1 Human Embryology and Genetics
- 17.2 Thalidomide as a Teratogen
- 17.3 Our Stolen Future
- 17.4 Therapeutic Cloning
18. Developmental Plasticity and Symbiosis
- 18.1 Inducible Caste Determination in Ant Colonies
- 18.2 Volvox: When Heat Brings Out Sex
- 18.3 Mechanisms of Diapause
- 18.4 Pressure as a Developmental Agent
- 18.5 The Dictyostelium Life Cycle: Variations within Variations
- 18.6 Developmental Symbioses and Parasitism
19. Developmental Mechanisms of Evolutionary Change
- 19.1 Relating Evolution to Development in the Nineteenth Century
- 19.2 Correlated Progression
- 19.3 The Search for the Urbilaterian Ancestor
- 19.4 How the Chordates Got a Head
- 19.5 "Intelligent Design" and Evolutionary Developmental Biology